Vesicular Stomatitis Virus (VSV) Therapy of Tumors
نویسندگان
چکیده
منابع مشابه
Oncotargeting by Vesicular Stomatitis Virus (VSV): Advances in Cancer Therapy
Modern oncotherapy approaches are based on inducing controlled apoptosis in tumor cells. Although a number of apoptosis-induction approaches are available, site-specific delivery of therapeutic agents still remain the biggest hurdle in achieving the desired cancer treatment benefit. Additionally, systemic treatment-induced toxicity remains a major limiting factor in chemotherapy. To specificall...
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i Acknowledgments ii Table of
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Vesicular stomatitis virus (VSV) is highly immunogenic and able to stimulate both innate and adaptive immune responses. However, its ability to induce adverse effects has held back the use of VSV as a potential vaccine vector. In this study we developed VSV-ΔP, a safe yet potent replication-defective recombinant VSV in which the phosphoprotein (P) gene was deleted. VSV-ΔP replicated only in sup...
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The fusiogenic envelope G glycoprotein of the vesicular stomatitis virus (VSV-G) that has been used to pseudotype retrovirus and lentivirus vectors can be used alone as an efficient vehicle for gene transfer. VSV-G protein is secreted into the culture medium as sendimentable vesicles from cells transfected with a VSV-G expression plasmid in the absence of other viral components. The VSV-G vesic...
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The effect of VSV infection in rabbit eye was investigated. The findings indicated that maximum virus growth in the rabbit cornea coincided with peak keratitis on postinfection day 1. Thereafter, keratitis was generally not observed, whereas infectious virus was detected in the cornea through day 6. Primary virus infection in the cornea of one eye produced serum-neutralizing antibody which did ...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2000
ISSN: 1521-6543
DOI: 10.1080/713803696